Purification of folate binding factor in normal umbilical cord serum.

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Purification of folate binding factor in normal umbilical cord serum.

Human umbilical cord serum was found to contain both free folate and folate complexed to a high-molecular weight factor. The complexed folate was bound to a very high affinity binder and was present in concentrations equivalent to as much as 60 ng of 5-methyltetrahydrofolic acid per ml of serum. Acidification of the serum caused disassociation of the folate-binder complex. Released folates were...

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Among blood preparations, serum has been topically used in the management of various ocular diseases in ophthalmology. Like peripheral blood serum, umbilical cord blood serum contains a high concentration of essential tear components, growth factors, neurotrophic factors, vitamin A, fibronectin, prealbumin, and oil. Umbilical cord serum can provide basic nutrients for epithelial renewal and can...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1975

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.72.11.4261